Intestinal Mucosal Mechanisms Controlling Iron Absorption
نویسندگان
چکیده
منابع مشابه
Studies on Iron Absorption. Intestinal Regulatory Mechanisms.
Recent studies (1-3) have indicated that gastrointestinal absorption of iron is a more complicated process than was initially postulated (4, 5). For example, several investigators have proposed as the result of studies in rats (2, 3), dogs (6), and humans (7) that iron absorption involves at least 2 steps: 1) mucosal uptake of iron from the intestinal lumen and 2) transfer of iron from mucosal ...
متن کاملIntestinal Iron Absorption
proteins that transfer electrons and manage oxygen. Until recently, there was little molecular understanding of how mammalian tissues meet the challenge of acquiring adequate amounts of iron without risking the toxic effects of iron excess. Our current knowledge of mammalian iron physiology and homeostasis is painted in broad brushstrokes, with many details remaining to be discovered. This revi...
متن کاملTOPIC HIGHLIGHT Molecular mechanisms involved in intestinal iron absorption
Iron is an essential trace metal in the human diet due to its obligate role in a number of metabolic processes. In the diet, iron is present in a number of different forms, generally described as haem (from haemoglobin and myoglobin in animal tissue) and non-haem iron (including ferric oxides and salts, ferritin and lactoferrin). This review describes the molecular mechanisms that co-ordinate t...
متن کاملIntestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase.
Hemoglobin and myoglobin are a major source of dietary iron in man. Heme, separated from these hemoproteins by intraluminal proteolysis, is absorbed intact by the intestinal mucosa. The absorbed heme is cleaved in the mucosal cell releasing inorganic iron. Although this mucosal heme-splitting activity initially was ascribed to xanthine oxidase, we investigated the possibility that it is catalyz...
متن کاملSystemic regulation of intestinal iron absorption.
The intestinal absorption of the essential trace element iron and its mobilization from storage sites in the body are controlled by systemic signals that reflect tissue iron requirements. Recent advances have indicated that the liver-derived peptide hepcidin plays a central role in this process by repressing iron release from intestinal enterocytes, macrophages and other body cells. When iron r...
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ژورنال
عنوان ژورنال: Blood
سال: 1963
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v22.4.406.406